Linker Information

General Information of This Linker
Linker ID
LIN0KRGMX
Linker Name
WO2024140449A1+ADC13+Linker
Linker Type
Cathepsin-cleavable linker
Antibody-Linker Relation
Cleavable
Structure
Formula
C17H31BrN4O7
Isosmiles
O=C(CBr)NCCOCCOCCC(NCC(N[C@@H](CCCCN)C(O)=O)=O)=O
InChI
InChI=1S/C17H31BrN4O7/c18-11-15(24)20-6-8-29-10-9-28-7-4-14(23)21-12-16(25)22-13(17(26)27)3-1-2-5-19/h13H,1-12,19H2,(H,20,24)(H,21,23)(H,22,25)(H,26,27)/t13-/m0/s1
InChIKey
LXBQUZVOBQTMKN-ZDUSSCGKSA-N
Pharmaceutical Properties
Molecule Weight
483.36
Polar area
169.08
Complexity
464.4299824
xlogp Value
-1.2646
Heavy Count
29
Rot Bonds
18
Hbond acc
7
Hbond Donor
5
Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
wO2024140449A1 ADC13 [Investigative]
 ADC Info 
Revealed Based on the Cell Line Data
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (lC50)
5-50 nM
Method Description
A Cell line test on OE-33
In Vitro Model Barrett adenocarcinoma, Adenocarcinoma of the esophagus OE-33 cells CVCL_0471
wO2024140449A1 ADC16 [Investigative]
 ADC Info 
Revealed Based on the Cell Line Data
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (lC50)
5-50 nM
Method Description
A Cell line test on OE-33
In Vitro Model Barrett adenocarcinoma, Adenocarcinoma of the esophagus OE-33 cells CVCL_0471
wO2024140449A1 ADC14 [Investigative]
 ADC Info 
Revealed Based on the Cell Line Data
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (lC50)
50-500 nM
Method Description
A Cell line test on OE-33
In Vitro Model Barrett adenocarcinoma, Adenocarcinoma of the esophagus OE-33 cells CVCL_0471
References
Ref 1 Antibody-drug conjugates of N-oxacycloalkyl substituted camptothecin derivatives