Linker Information
General Information of This Linker
| Linker ID |
LIN0KMNRX
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| Linker Name |
CN110997010A ADC-8 linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C68H101N9O27S2
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| Isosmiles |
C[C@H](NC([C@@H](NC(CCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCN1C(C=CC1=O)=O)=O)=O)C(C)C)=O)C(NC2=CC=C(COC(NC(CSC(CC3=O)C(N3CCCCCC(O)=O)=O)C(NC(C(O)=O)CSC(C4=O)CC(N4CCCCCC(O)=O)=O)=O)=O)C=C2)=O
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| InChI |
InChI=1S/C68H101N9O27S2/c1-45(2)61(74-54(79)19-24-96-26-28-98-30-32-100-34-36-102-38-39-103-37-35-101-33-31-99-29-27-97-25-20-69-53(78)18-23-75-55(80)16-17-56(75)81)64(90)70-46(3)62(88)71-48-14-12-47(13-15-48)42-104-68(95)73-49(43-105-51-40-57(82)76(65(51)91)21-8-4-6-10-59(84)85)63(89)72-50(67(93)94)44-106-52-41-58(83)77(66(52)92)22-9-5-7-11-60(86)87/h12-17,45-46,49-52,61H,4-11,18-44H2,1-3H3,(H,69,78)(H,70,90)(H,71,88)(H,72,89)(H,73,95)(H,74,79)(H,84,85)(H,86,87)(H,93,94)/t46-,49?,50?,51?,52?,61-/m0/s1
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| InChIKey |
ITPYYQWVKYLIEM-NCMQAGPYSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1540.726
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Polar area
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481.71
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Complexity
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2917.467464
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xlogp Value
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0.4004
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Heavy Count
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106
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Rot Bonds
|
60
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Hbond acc
|
26
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Hbond Donor
|
9
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Each Antibody-drug Conjugate Related to This Linker