Linker Information
General Information of This Linker
| Linker ID |
LIN0KGCUG
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| Linker Name |
Linker of ADC1-2
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C38H55N9O13
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| Isosmiles |
CC([C@H](NC([C@@H](NC(CCCCCN1C(C=CC1=O)=O)=O)CCC(NC2[C@H](O)[C@H](O)[C@@H](C(N)=O)O2)=O)=O)C(N[C@@H](CCCNC(N)=O)C(NC3=CC=C(CO)C=C3)=O)=O)C
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| InChI |
InChI=1S/C38H55N9O13/c1-20(2)29(36(58)44-23(7-6-17-41-38(40)59)34(56)42-22-11-9-21(19-48)10-12-22)46-35(57)24(13-14-26(50)45-37-31(54)30(53)32(60-37)33(39)55)43-25(49)8-4-3-5-18-47-27(51)15-16-28(47)52/h9-12,15-16,20,23-24,29-32,37,48,53-54H,3-8,13-14,17-19H2,1-2H3,(H2,39,55)(H,42,56)(H,43,49)(H,44,58)(H,45,50)(H,46,57)(H3,40,41,59)/t23-,24-,29-,30-,31+,32-,37?/m0/s1
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| InChIKey |
NXYYHKRAKWDEAK-PIKIQYGUSA-N
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| Pharmaceutical Properties |
Molecule Weight
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845.908
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Polar area
|
351.01
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Complexity
|
1660.695341
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xlogp Value
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-3.0099
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Heavy Count
|
60
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Rot Bonds
|
24
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Hbond acc
|
13
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Hbond Donor
|
11
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Each Antibody-drug Conjugate Related to This Linker