Linker Information
General Information of This Linker
| Linker ID |
LIN0JZMWM
|
|||||
|---|---|---|---|---|---|---|
| Linker Name |
CN116916962A-C-30-linker
|
|||||
| Linker Type |
Unclear
|
|||||
| Antibody-Linker Relation |
Cleavable
|
|||||
| Structure |
|
|||||
| Formula |
C25H42N4O8
|
|||||
| Isosmiles |
C[C@H](NC([C@@H](NC(COCCOCCOCCOCCN)=O)C(C)C)=O)C(NC1=CC=C(CO)C=C1)=O
|
|||||
| InChI |
InChI=1S/C25H42N4O8/c1-18(2)23(25(33)27-19(3)24(32)28-21-6-4-20(16-30)5-7-21)29-22(31)17-37-15-14-36-13-12-35-11-10-34-9-8-26/h4-7,18-19,23,30H,8-17,26H2,1-3H3,(H,27,33)(H,28,32)(H,29,31)/t19-,23-/m0/s1
|
|||||
| InChIKey |
PQIJWDBMSFZICY-CVDCTZTESA-N
|
|||||
| Pharmaceutical Properties |
Molecule Weight
|
526.631
|
Polar area
|
170.47
|
||
|
Complexity
|
746.7479189
|
xlogp Value
|
-0.212
|
|||
|
Heavy Count
|
37
|
Rot Bonds
|
20
|
|||
|
Hbond acc
|
9
|
Hbond Donor
|
5
|
|||
Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
CN116916962A-ADC-B15 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
302 nM
|
High hCCR2 expression (hCCR2+++) | ||
| Method Description |
THP 1, 15,000cells/254uL per welld were plated at set in 384 well flat plate, in the appropriate growth media. The cell plates were dosed with 5uL of the hCCR2 targeting-ADC samples and then incubated at 37°C for 20 hours. At the end of the incubation 10uL/well of the QUANTJ-LucTM (InvivoGenftrep-qlc1) were added and luminescence was measured immediately using the LeadSeeker.
Click to Show/Hide
|
||||
| In Vitro Model | Acute monoblastic/monocytic leukemia, Childhood acute monocytic leukemia | THP1 cells | CVCL_0006 | ||