Linker Information
General Information of This Linker
| Linker ID |
LIN0JXDIM
|
|||||
|---|---|---|---|---|---|---|
| Linker Name |
Anti-Her2-AL1- LP22 linker
|
|||||
| Linker Type |
Cathepsin-cleavable linker
|
|||||
| Antibody-Linker Relation |
Cleavable
|
|||||
| Structure |
|
|||||
| Formula |
C55H90N12O20
|
|||||
| Isosmiles |
NCCOCCOCCOCCN(N=N1)C2=C1CC(OCC(NCCOCCOCCOCCOCCC(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@H](CCCNC(N)=O)C(NC3=CC=C(C=C3)COC(NCC(O)=O)=O)=O)=O)C(C)C)=O)=O)=O)CCCC2
|
|||||
| InChI |
InChI=1S/C55H90N12O20/c1-38(2)50(53(76)63-42(7-5-17-59-54(57)77)51(74)61-40-11-9-39(10-12-40)36-87-55(78)60-35-49(72)73)64-52(75)43(13-14-48(70)71)62-46(68)15-20-79-24-28-83-32-33-85-30-26-81-22-18-58-47(69)37-86-41-6-3-4-8-45-44(34-41)65-66-67(45)19-23-82-27-31-84-29-25-80-21-16-56/h9-12,38,41-43,50H,3-8,13-37,56H2,1-2H3,(H,58,69)(H,60,78)(H,61,74)(H,62,68)(H,63,76)(H,64,75)(H,70,71)(H,72,73)(H3,57,59,77)/t41?,42-,43-,50-/m0/s1
|
|||||
| InChIKey |
IQCHFABOBQBDOO-DQEWLHDQSA-N
|
|||||
| Pharmaceutical Properties |
Molecule Weight
|
1239.389
|
Polar area
|
444.12
|
||
|
Complexity
|
2253.682924
|
xlogp Value
|
-1.1134
|
|||
|
Heavy Count
|
87
|
Rot Bonds
|
48
|
|||
|
Hbond acc
|
22
|
Hbond Donor
|
11
|
|||
Each Antibody-drug Conjugate Related to This Linker