Linker Information
General Information of This Linker
| Linker ID |
LIN0JWHJV
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| Linker Name |
ADC2-62-1 Linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C51H78N14O18
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| Isosmiles |
CC([C@H](NC([C@@H](NC(CCNC(CN1C(CCC1=O)=O)=O)=O)CCC(NC[C@@H](O2)[C@@H](O)[C@@H](O)[C@@H]2CC(N(CC(N(C)CC(N(C)CC(N(C)CC(N)=O)=O)=O)=O)C)=O)=O)=O)C(N[C@@H](CCCNC(N)=O)C(NC3=CC=C(C=C3)CO)=O)=O)C
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| InChI |
InChI=1S/C51H78N14O18/c1-28(2)45(50(81)59-31(8-7-18-55-51(53)82)48(79)57-30-11-9-29(27-66)10-12-30)60-49(80)32(58-37(69)17-19-54-38(70)23-65-39(71)15-16-40(65)72)13-14-36(68)56-21-34-47(78)46(77)33(83-34)20-41(73)62(4)24-43(75)64(6)26-44(76)63(5)25-42(74)61(3)22-35(52)67/h9-12,28,31-34,45-47,66,77-78H,7-8,13-27H2,1-6H3,(H2,52,67)(H,54,70)(H,56,68)(H,57,79)(H,58,69)(H,59,81)(H,60,80)(H3,53,55,82)/t31-,32-,33-,34+,45-,46-,47+/m0/s1
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| InChIKey |
PIWGWZZDXHECQH-VKIJDCRWSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1175.265
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Polar area
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461.35
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Complexity
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2407.397478
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xlogp Value
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-6.5738
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Heavy Count
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83
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Rot Bonds
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33
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Hbond acc
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18
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Hbond Donor
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12
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Each Antibody-drug Conjugate Related to This Linker