Linker Information
General Information of This Linker
| Linker ID |
LIN0JSNKK
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| Linker Name |
Aminobenzazepine-linker Formula II-42
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| Linker Type |
Unclear
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| Antibody-Linker Relation |
Cleavable
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| Formula |
C12H10F4O5
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| Isosmiles |
FC1=CC(F)=C(F)C(OC(CCOCCC(O)=O)=O)=C1F
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| InChI |
InChI=1S/C12H10F4O5/c13-6-5-7(14)11(16)12(10(6)15)21-9(19)2-4-20-3-1-8(17)18/h5H,1-4H2,(H,17,18)
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| InChIKey |
NZSIPPJLVQUAPF-UHFFFAOYSA-N
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| Pharmaceutical Properties |
Molecule Weight
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310.199
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Polar area
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72.83
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Complexity
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491.0801149
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xlogp Value
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2.0298
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Heavy Count
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21
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Rot Bonds
|
7
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Hbond acc
|
4
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Hbond Donor
|
1
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
AU2020291014A1 IC-31 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
17.2 nM
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| Method Description |
Mycloid TNFa Secretion
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| In Vitro Model | Mycloid | Mycloid cells | Homo sapiens | ||