Linker Information

General Information of This Linker

Linker ID	LIN0JLFQA
Linker Name	Mal-PEG4-Val-Cit-PABC
Linker Type	Thiol-sensitive linker
Antibody-Linker Relation	Cleavable
Structure
Structure	3D MOL		2D MOL
Formula	C36H55N7O12
Isosmiles	CC(C)[C@@H](C(=O)N[C@@H](CCCNC(=O)N)C(=O)NC1=CC=C(C=C1)CO)NC(=O)CCOCCOCCOCCOCCNC(=O)CCN2C(=O)C=CC2=O
PubChem CID	129280705
InChI	InChI=1S/C36H55N7O12/c1-25(2)33(35(50)41-28(4-3-13-39-36(37)51)34(49)40-27-7-5-26(24-44)6-8-27)42-30(46)12-16-52-18-20-54-22-23-55-21-19-53-17-14-38-29(45)11-15-43-31(47)9-10-32(43)48/h5-10,25,28,33,44H,3-4,11-24H2,1-2H3,(H,38,45)(H,40,49)(H,41,50)(H,42,46)(H3,37,39,51)/t28-,33-/m0/s1
InChIKey	PEGLOOGTSQEDBL-UVMMSNCQSA-N
IUPAC Name	(2S)-5-(carbamoylamino)-2-[[(2S)-2-[3-[2-[2-[2-[2-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]propanoylamino]-3-methylbutanoyl]amino]-N-[4-(hydroxymethyl)phenyl]pentanamide
Pharmaceutical Properties	Molecule Weight	777.9	Polar area	266
	Complexity	1240	xlogp Value	-2.4
	Heavy Count	55	Rot Bonds	29
	Hbond acc	12	Hbond Donor	7

Each Antibody-drug Conjugate Related to This Linker

Full Information of The Activity Data of The ADC(s) Related to This Linker

DAB4-DuoDM [Investigative]

ADC Info

Discovered Using Cell Line-derived Xenograft Model

Click To Hide/Show 1 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Tumor Growth Inhibition value (TGI)	≈ 71.40% (Day 8)	Positive La/SSB expression (La/SSB +++/++)
Method Description	A549 tumor-bearing mice were treated intraperitoneally with 150 mg/kg gemcitabine and 3 mg/kg cisplatin on Day 1. The day after chemotherapy, mice were treated with an intravenous injection of ADC.
In Vivo Model	A549 CDX model
In Vitro Model	Lung adenocarcinoma	A-549 cells		CVCL_0023

References

Ref 1	APOMAB Antibody-Drug Conjugates Targeting Dead Tumor Cells are Effective In Vivo. Mol Cancer Ther. 2019 Feb;18(2):335-345. doi: 10.1158/1535-7163.MCT-18-0842. Epub 2018 Nov 9.