Linker Information
General Information of This Linker
| Linker ID |
LIN0JJWVU
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| Linker Name |
(Linker-03)SMCC-TAZ-PEG-VC-PAB
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C59H88N10O17
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| Isosmiles |
OCC1=CC=C(C=C1)NC([C@H](CCCCN)NC([C@@H](CC2=CC=CC=C2)NC(COCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCN3N=NC(CNC([C@@H]4CCC(CC4)CN5C(C=CC5=O)=O)=O)=C3)=O)=O)=O)=O
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| InChI |
InChI=1S/C59H88N10O17/c60-19-5-4-8-51(58(76)63-49-15-11-47(42-70)12-16-49)65-59(77)52(38-45-6-2-1-3-7-45)64-54(72)44-86-43-53(71)61-20-22-78-24-26-80-28-30-82-32-34-84-36-37-85-35-33-83-31-29-81-27-25-79-23-21-68-41-50(66-67-68)39-62-57(75)48-13-9-46(10-14-48)40-69-55(73)17-18-56(69)74/h1-3,6-7,11-12,15-18,41,46,48,51-52,70H,4-5,8-10,13-14,19-40,42-44,60H2,(H,61,71)(H,62,75)(H,63,76)(H,64,72)(H,65,77)/t46?,48?,51-,52+/m0/s1
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| InChIKey |
FAEZAUCVBDZTEW-BRCNRIRRSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1209.406
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Polar area
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342.91
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Complexity
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2343.190398
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xlogp Value
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0.3636
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Heavy Count
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86
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Rot Bonds
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48
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Hbond acc
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21
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Hbond Donor
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7
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
wO2024169913A1 ADC01-08-4 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
0.0179 nM
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High HER2 expression (HER2+++) | ||
| Method Description |
Cytotoxicity of ADC to SK-BR-3 cells
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| In Vitro Model | Breast adenocarcinoma | SK-BR-3 cells | CVCL_0033 | ||