Linker Information
General Information of This Linker
| Linker ID |
LIN0JIHXZ
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| Linker Name |
Linker of ADC1-11
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C47H73N9O17
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| Isosmiles |
CC([C@H](NC([C@@H](NC(CCCCCN1C(C=CC1=O)=O)=O)CCC(NC2[C@H](O)[C@H](O)[C@@H](C(NCCOCCOCCOCCOC)=O)O2)=O)=O)C(N[C@@H](CCCNC(N)=O)C(NC3=CC=C(CO)C=C3)=O)=O)C
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| InChI |
InChI=1S/C47H73N9O17/c1-29(2)38(44(66)53-32(8-7-18-50-47(48)68)42(64)51-31-12-10-30(28-57)11-13-31)55-43(65)33(52-34(58)9-5-4-6-20-56-36(60)16-17-37(56)61)14-15-35(59)54-46-40(63)39(62)41(73-46)45(67)49-19-21-70-24-25-72-27-26-71-23-22-69-3/h10-13,16-17,29,32-33,38-41,46,57,62-63H,4-9,14-15,18-28H2,1-3H3,(H,49,67)(H,51,64)(H,52,58)(H,53,66)(H,54,59)(H,55,65)(H3,48,50,68)/t32-,33-,38-,39-,40+,41-,46?/m0/s1
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| InChIKey |
KMZKJIZCNAZXLG-RMJDCMHISA-N
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| Pharmaceutical Properties |
Molecule Weight
|
1036.147
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Polar area
|
373.94
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Complexity
|
1881.415521
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xlogp Value
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-2.6828
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Heavy Count
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73
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Rot Bonds
|
36
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Hbond acc
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17
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Hbond Donor
|
11
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Each Antibody-drug Conjugate Related to This Linker