Linker Information
General Information of This Linker
| Linker ID |
LIN0JFMIE
|
|||||
|---|---|---|---|---|---|---|
| Name |
Mal-Val-Lys (PEG24)-Cit-PAB
|
|||||
| Linker Type |
Cathepsin-cleavable linker
|
|||||
| Antibody-Linker Relation |
Cleavable
|
|||||
| Structure |
|
|||||
| Formula |
C30H43N7O9
|
|||||
| Isosmiles |
CC([C@H](NC(CNC(CCN1C(C=CC1=O)=O)=O)=O)C(N[C@@H](CCCNC(NCCOC)=O)C(NC2=CC=C(CO)C=C2)=O)=O)C
|
|||||
| InChI |
InChI=1S/C30H43N7O9/c1-19(2)27(36-24(40)17-33-23(39)12-15-37-25(41)10-11-26(37)42)29(44)35-22(5-4-13-31-30(45)32-14-16-46-3)28(43)34-21-8-6-20(18-38)7-9-21/h6-11,19,22,27,38H,4-5,12-18H2,1-3H3,(H,33,39)(H,34,43)(H,35,44)(H,36,40)(H2,31,32,45)/t22-,27-/m0/s1
|
|||||
| InChIKey |
BTCOWOUXUOUMHK-CUNXSJBXSA-N
|
|||||
| Pharmaceutical Properties |
Molecule Weight
|
645.714
|
Polar area
|
224.37
|
||
|
Complexity
|
1190.99279
|
xlogp Value
|
-1.0999
|
|||
|
Heavy Count
|
46
|
Rot Bonds
|
19
|
|||
|
Hbond acc
|
9
|
Hbond Donor
|
7
|
|||
Each Antibody-drug Conjugate Related to This Linker