Linker Information
General Information of This Linker
| Linker ID |
LIN0JCLCZ
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| Linker Name |
COT-GGG linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Formula |
C16H25N3O6
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| Isosmiles |
OC(CNC(CNC(CNC(COC1CCCCC/C=C\1)=O)=O)=O)=O
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| InChI |
InChI=1S/C16H25N3O6/c20-13(17-8-14(21)19-10-16(23)24)9-18-15(22)11-25-12-6-4-2-1-3-5-7-12/h4,6,12H,1-3,5,7-11H2,(H,17,20)(H,18,22)(H,19,21)(H,23,24)/b6-4-
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| InChIKey |
AESVSOQYPYXGTE-XQRVVYSFSA-N
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| Pharmaceutical Properties |
Molecule Weight
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355.391
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Polar area
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133.83
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Complexity
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474.2667787
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xlogp Value
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-0.6749
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Heavy Count
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25
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Rot Bonds
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9
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Hbond acc
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5
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Hbond Donor
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4
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
TRSQ-ZP3A-LP5 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
0.09 nM
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Positive HER2 expression (HER2+++/++) | ||
| Method Description |
The anti-proliferation test was carried out with SK-BR-3 human breast cancer cell line. Cells were grown in McCoy's 5a medium supplemented with 11% FBS,penicillin/streptomycin and L-glutamine.
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| In Vitro Model | Breast adenocarcinoma | SK-BR-3 cells | CVCL_0033 | ||