Linker Information
General Information of This Linker
| Linker ID |
LIN0JCGGZ
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| Linker Name |
WO2024140449A1+ADC9+Linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C25H35BrN6O8
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| Isosmiles |
O=C(N1)C(CBr)=NC2=C1C=C(C=C2)C(NCCOCCOCCC(NCC(N[C@@H](CCCCN)C(O)=O)=O)=O)=O
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| InChI |
InChI=1S/C25H35BrN6O8/c26-14-20-24(36)32-19-13-16(4-5-17(19)30-20)23(35)28-8-10-40-12-11-39-9-6-21(33)29-15-22(34)31-18(25(37)38)3-1-2-7-27/h4-5,13,18H,1-3,6-12,14-15,27H2,(H,28,35)(H,29,33)(H,31,34)(H,32,36)(H,37,38)/t18-/m0/s1
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| InChIKey |
UUCOEFQAUIDOCP-SFHVURJKSA-N
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| Pharmaceutical Properties |
Molecule Weight
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627.493
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Polar area
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214.83
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Complexity
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1150.264175
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xlogp Value
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-0.2143
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Heavy Count
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40
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Rot Bonds
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19
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Hbond acc
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9
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Hbond Donor
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6
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
wO2024140449A1 ADC10 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
5-50 nM
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| Method Description |
A Cell line test on OE-33
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| In Vitro Model | Barrett adenocarcinoma, Adenocarcinoma of the esophagus | OE-33 cells | CVCL_0471 | ||
wO2024140449A1 ADC12 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
5-50 nM
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| Method Description |
A Cell line test on OE-33
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| In Vitro Model | Barrett adenocarcinoma, Adenocarcinoma of the esophagus | OE-33 cells | CVCL_0471 | ||