Linker Information
General Information of This Linker
| Linker ID |
LIN0JCEWZ
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| Linker Name |
Linker of ADC2-53
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C36H49N9O17S
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| Isosmiles |
O=C(NCC(NCC(N[C@@H](CC1=CC=CC=C1)C(NCC(O)=O)=O)=O)=O)[C@@H](NC(CCNC(CNC(/C=C\C(O)=O)=O)=O)=O)CCC(NC[C@H](O2)[C@H](O)[C@@H](O)[C@H](O)[C@H]2C(N)=O)=O.[S]
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| InChI |
InChI=1S/C36H49N9O17.S/c37-34(59)33-32(58)31(57)30(56)21(62-33)13-39-22(46)7-6-19(44-24(48)10-11-38-25(49)14-40-23(47)8-9-28(52)53)35(60)42-15-26(50)41-16-27(51)45-20(36(61)43-17-29(54)55)12-18-4-2-1-3-5-18;/h1-5,8-9,19-21,30-33,56-58H,6-7,10-17H2,(H2,37,59)(H,38,49)(H,39,46)(H,40,47)(H,41,50)(H,42,60)(H,43,61)(H,44,48)(H,45,51)(H,52,53)(H,54,55);/b9-8-;/t19-,20-,21-,30-,31+,32-,33-;/m0./s1
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| InChIKey |
XAKHRBLESRUQBW-HOKAEBHDSA-N
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| Pharmaceutical Properties |
Molecule Weight
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911.901
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Polar area
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420.41
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Complexity
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1744.968753
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xlogp Value
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-7.2248
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Heavy Count
|
63
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Rot Bonds
|
25
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Hbond acc
|
15
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Hbond Donor
|
14
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Each Antibody-drug Conjugate Related to This Linker