Linker Information
General Information of This Linker
| Linker ID |
LIN0IYGZD
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| Linker Name |
Linker of ADC2-42
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C37H51N9O17S
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| Isosmiles |
O=C(NCC(NCC(N[C@@H](CC1=CC=CC=C1)C(NCC(O)=O)=O)=O)=O)[C@@H](NC(CCNC(CCNC(CNC(/C=C\C(O)=O)=O)=O)=O)=O)CCC(NC(O2)[C@H](O)[C@H](O)[C@H]2CO)=O.[S]
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| InChI |
InChI=1S/C37H51N9O17.S/c47-19-23-33(59)34(60)37(63-23)46-26(50)7-6-21(44-27(51)11-13-38-25(49)10-12-39-28(52)15-40-24(48)8-9-31(55)56)35(61)42-16-29(53)41-17-30(54)45-22(36(62)43-18-32(57)58)14-20-4-2-1-3-5-20;/h1-5,8-9,21-23,33-34,37,47,59-60H,6-7,10-19H2,(H,38,49)(H,39,52)(H,40,48)(H,41,53)(H,42,61)(H,43,62)(H,44,51)(H,45,54)(H,46,50)(H,55,56)(H,57,58);/b9-8-;/t21-,22-,23+,33+,34+,37?;/m0./s1
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| InChIKey |
KMAVHUZXXOOMHY-SAZJFVGJSA-N
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| Pharmaceutical Properties |
Molecule Weight
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925.928
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Polar area
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406.42
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Complexity
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1744.968753
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xlogp Value
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-6.6149
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Heavy Count
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64
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Rot Bonds
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27
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Hbond acc
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15
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Hbond Donor
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14
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Each Antibody-drug Conjugate Related to This Linker