Linker Information
General Information of This Linker
| Linker ID |
LIN0ISLBJ
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| Linker Name |
CN119343152A Trastuzumab-GDP-D-P2/P4-P4-GGFG-Dxd Linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C82H132N18O34
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| Isosmiles |
O=C(NCC(NCC(N[C@H](C(NCC(O)=O)=O)CC1=CC=CC=C1)=O)=O)CNOCCOCCOCCOCC(N=N2)=CN2CCOCCOCCN(C(CCOCCOCCOCCOCCN(N=N3)C=C3COCCOCCOCCOCCC(NCC(NCC(N[C@H](C(O)NCC(O)=O)CC4=CC=CC=C4)=O)=O)O)=O)CCNC(CCC(NC[C@H]5[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)O5)=O)=O
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| InChI |
InChI=1S/C82H132N18O34/c101-66(11-12-67(102)84-47-65-77(114)78(115)79(116)82(119)134-65)83-15-16-98(17-22-122-27-28-123-23-18-99-55-61(94-96-99)58-132-42-40-129-37-38-130-43-44-133-91-52-71(106)86-49-70(105)88-51-73(108)93-64(81(118)90-54-76(112)113)46-60-9-5-2-6-10-60)74(109)14-21-121-26-31-126-33-34-127-32-29-124-24-19-100-56-62(95-97-100)57-131-41-39-128-36-35-125-30-25-120-20-13-68(103)85-48-69(104)87-50-72(107)92-63(80(117)89-53-75(110)111)45-59-7-3-1-4-8-59/h1-10,55-56,63-65,68,77-80,82,85,89,91,103,114-117,119H,11-54,57-58H2,(H,83,101)(H,84,102)(H,86,106)(H,87,104)(H,88,105)(H,90,118)(H,92,107)(H,93,108)(H,110,111)(H,112,113)/t63-,64-,65-,68?,77+,78+,79-,80?,82-/m0/s1
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| InChIKey |
PIFHMKSJKCFYHF-WWCLGQBZSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1914.05
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Polar area
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685.05
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Complexity
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.
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xlogp Value
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-9.3669
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Heavy Count
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134
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Rot Bonds
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82
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Hbond acc
|
41
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Hbond Donor
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19
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Each Antibody-drug Conjugate Related to This Linker