Linker Information
General Information of This Linker
| Linker ID |
LIN0IQAKX
|
|||||
|---|---|---|---|---|---|---|
| Linker Name |
DBCO-B-Glucuronide-PEG12
|
|||||
| Linker Type |
Cathepsin-cleavable linker
|
|||||
| Antibody-Linker Relation |
Cleavable
|
|||||
| Structure |
|
|||||
| Formula |
C67H97N5O25
|
|||||
| Isosmiles |
O=C(NC[C@H](NC(CCCCC(N1C2=C(C#CC(C=CC=C3)=C3C1)C=CC=C2)=O)=O)C(NCCC(NCC4=CC(CO)=CC=C4O[C@H]5[C@H](O)[C@@H](O)[C@@H]([C@H](O5)C(O)=O)O)=O)=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC
|
|||||
| InChI |
InChI=1S/C67H97N5O25/c1-84-22-23-86-26-27-88-30-31-90-34-35-92-38-39-94-42-43-95-41-40-93-37-36-91-33-32-89-29-28-87-25-24-85-21-19-58(75)70-46-54(71-59(76)12-6-7-13-60(77)72-47-52-10-3-2-8-50(52)15-16-51-9-4-5-11-55(51)72)65(81)68-20-18-57(74)69-45-53-44-49(48-73)14-17-56(53)96-67-63(80)61(78)62(79)64(97-67)66(82)83/h2-5,8-11,14,17,44,54,61-64,67,73,78-80H,6-7,12-13,18-43,45-48H2,1H3,(H,68,81)(H,69,74)(H,70,75)(H,71,76)(H,82,83)/t54-,61-,62-,63+,64-,67+/m0/s1
|
|||||
| InChIKey |
KQHONRXDRISTQK-XUTFWBAQSA-N
|
|||||
| Pharmaceutical Properties |
Molecule Weight
|
1372.523
|
Polar area
|
384.15
|
||
|
Complexity
|
2720.679155
|
xlogp Value
|
-0.1005
|
|||
|
Heavy Count
|
97
|
Rot Bonds
|
54
|
|||
|
Hbond acc
|
24
|
Hbond Donor
|
9
|
|||
Each Antibody-drug Conjugate Related to This Linker