Linker Information
General Information of This Linker
| Linker ID |
LIN0IPZHH
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| Linker Name |
DIBAC-GGFG linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Formula |
C34H34N6O6
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| Isosmiles |
O=C(NCC(NCC(N[C@@H](CC1=CC=CC=C1)C(NCC(N)=O)=O)=O)=O)CCC(N2C3=C(C=CC=C3)C#CC4=CC=CC=C4C2)=O
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| InChI |
InChI=1S/C34H34N6O6/c35-29(41)19-38-34(46)27(18-23-8-2-1-3-9-23)39-32(44)21-37-31(43)20-36-30(42)16-17-33(45)40-22-26-12-5-4-10-24(26)14-15-25-11-6-7-13-28(25)40/h1-13,27H,16-22H2,(H2,35,41)(H,36,42)(H,37,43)(H,38,46)(H,39,44)/t27-/m0/s1
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| InChIKey |
SZKCFGPBJSDMKM-MHZLTWQESA-N
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| Pharmaceutical Properties |
Molecule Weight
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622.682
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Polar area
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179.8
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Complexity
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1629.720298
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xlogp Value
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0.2746
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Heavy Count
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46
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Rot Bonds
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13
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Hbond acc
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6
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Hbond Donor
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5
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
TRSQ-ZP3A- LP20-Ve [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
0.04 nM
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Positive HER2 expression (HER2+++/++) | ||
| Method Description |
The anti-proliferation test was carried out with SK-BR-3 human breast cancer cell line. Cells were grown in McCoy's 5a medium supplemented with 41% FBS,penicillin/streptomycin and L-glutamine.
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| In Vitro Model | Breast adenocarcinoma | SK-BR-3 cells | CVCL_0033 | ||
TRSQ-ZP3A- LP24-Vb [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
0.04 nM
|
Positive HER2 expression (HER2+++/++) | ||
| Method Description |
The anti-proliferation test was carried out with SK-BR-3 human breast cancer cell line. Cells were grown in McCoy's 5a medium supplemented with 44% FBS,penicillin/streptomycin and L-glutamine.
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| In Vitro Model | Breast adenocarcinoma | SK-BR-3 cells | CVCL_0033 | ||