Linker Information
General Information of This Linker
| Linker ID |
LIN0INKSL
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| Linker Name |
Linker of ADC2-34
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C49H72N14O18
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| Isosmiles |
O=C(NCC(NCC(N[C@H](C(NCC(O)=O)=O)CC1=CC=CC=C1)=O)=O)[C@H](CCC(NC2[C@H](O)[C@H](O)[C@@H](C(N(CC(N(N(CC(N(N(CC(N(C)CC(N)=O)=O)C)C)=O)C)C)=O)C)=O)O2)=O)NC(CCCCCN3C(C=CC3=O)=O)=O
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| InChI |
InChI=1S/C49H72N14O18/c1-57(25-32(50)64)39(71)27-59(3)62(6)41(73)28-60(4)61(5)40(72)26-58(2)49(80)45-43(76)44(77)48(81-45)56-34(66)17-16-30(54-33(65)15-11-8-12-20-63-37(69)18-19-38(63)70)46(78)52-22-35(67)51-23-36(68)55-31(47(79)53-24-42(74)75)21-29-13-9-7-10-14-29/h7,9-10,13-14,18-19,30-31,43-45,48,76-77H,8,11-12,15-17,20-28H2,1-6H3,(H2,50,64)(H,51,67)(H,52,78)(H,53,79)(H,54,65)(H,55,68)(H,56,66)(H,74,75)/t30-,31-,43-,44+,45-,48?/m0/s1
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| InChIKey |
ITEKGAUKOZESBP-BREZDYFMSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1145.195
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Polar area
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429.78
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Complexity
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2390.460955
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xlogp Value
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-7.5271
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Heavy Count
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81
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Rot Bonds
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33
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Hbond acc
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19
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Hbond Donor
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10
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Each Antibody-drug Conjugate Related to This Linker