Linker Information
General Information of This Linker
| Linker ID |
LIN0INFQA
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|---|---|---|---|---|---|---|
| Linker Name |
DBCO-4,6nnAA-PEG-VKG
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C68H106N6O20
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| Isosmiles |
O=C(N1CCC2(CC(C2)C(NCCC(N3CC4=C(C#CC5=C3C=CC=C5)C=CC=C4)=O)=O)CC1)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(O)=O)=O)=O
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| InChI |
InChI=1S/C68H106N6O20/c1-54(2)64(66(79)71-59(67(80)81)12-7-8-21-69)72-61(75)17-25-82-27-29-84-31-33-86-35-37-88-39-41-90-43-45-92-47-49-94-50-48-93-46-44-91-42-40-89-38-36-87-34-32-85-30-28-83-26-18-62(76)73-23-19-68(20-24-73)51-58(52-68)65(78)70-22-16-63(77)74-53-57-11-4-3-9-55(57)14-15-56-10-5-6-13-60(56)74/h3-6,9-11,13,54,58-59,64H,7-8,12,16-53,69H2,1-2H3,(H,70,78)(H,71,79)(H,72,75)(H,80,81)/t59-,64-/m0/s1
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| InChIKey |
MEUSASQZMZPZGK-CQEHKKIPSA-N
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| Pharmaceutical Properties |
Molecule Weight
|
1327.618
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Polar area
|
311.23
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Complexity
|
2419.838437
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xlogp Value
|
3.2933
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Heavy Count
|
94
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Rot Bonds
|
55
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Hbond acc
|
20
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Hbond Donor
|
5
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Each Antibody-drug Conjugate Related to This Linker