Linker Information
General Information of This Linker
| Linker ID |
LIN0ILZYL
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| Linker Name |
CN119317630A ADC-C13 Linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C17H28N4O9
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| Isosmiles |
CC([C@H](NC(CCNC(CNC(CCC(O)=O)=O)=O)=O)C(N[C@@H](CO)C(O)=O)=O)C
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| InChI |
InChI=1S/C17H28N4O9/c1-9(2)15(16(28)20-10(8-22)17(29)30)21-12(24)5-6-18-13(25)7-19-11(23)3-4-14(26)27/h9-10,15,22H,3-8H2,1-2H3,(H,18,25)(H,19,23)(H,20,28)(H,21,24)(H,26,27)(H,29,30)/t10-,15-/m0/s1
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| InChIKey |
XFKCJWHEGGFGDY-BONVTDFDSA-N
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| Pharmaceutical Properties |
Molecule Weight
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432.43
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Polar area
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211.23
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Complexity
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609.9495685
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xlogp Value
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-2.8238
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Heavy Count
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30
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Rot Bonds
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14
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Hbond acc
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7
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Hbond Donor
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7
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
CN119317630A ADC-C13 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
73 nM
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| Method Description |
Distribute the cell lines H358 (1E3/well), to 3D-96-well plates (Corning: 4520), with 80 ul/well. Incubate overnight at 37°C and 5% CO2. Detect the cell viability of H358, H441, H1048 and MDA-MB-453 cells using 3D reagent (Promega, G9683).
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| In Vitro Model | Minimally invasive lung adenocarcinoma | H358 cells | CVCL_1559 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
95 nM
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| Method Description |
Distribute the cell lines H1048 (1E3/well) to 3D-96-well plates (Corning: 4520), with 80 ul/well. Incubate overnight at 37°C and 5% CO2. Detect the cell viability of H358, H441, H1048 and MDA-MB-453 cells using 3D reagent (Promega, G9683).
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| In Vitro Model | Lung small cell carcinoma, Small cell lung cancer | H1048 cells | CVCL_1453 | ||
| Experiment 3 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
100 nM
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| Method Description |
Distribute the cell lines H441 (1E3/well) to 3D-96-well plates (Corning: 4520), with 80 ul/well. Incubate overnight at 37°C and 5% CO2. Detect the cell viability of H358, H441, H1048 and MDA-MB-453 cells using 3D reagent (Promega, G9683).
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| In Vitro Model | Lung papillary adenocarcinoma | H441 cells | CVCL_1561 | ||