Linker Information
General Information of This Linker
| Linker ID |
LIN0IJZUH
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| Linker Name |
Mal-Pro-D-Lys
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C20H32N6O5
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| Isosmiles |
NCCCCC(N)C(=O)N1CCCC1C(=O)NCCNC(=O)CCN1C(=O)C=CC1=O
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| InChI |
InChI=1S/C20H32N6O5/c21-9-2-1-4-14(22)20(31)25-12-3-5-15(25)19(30)24-11-10-23-16(27)8-13-26-17(28)6-7-18(26)29/h6-7,14-15H,1-5,8-13,21-22H2,(H,23,27)(H,24,30)
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| InChIKey |
KWFKNDBTVMWHKI-UHFFFAOYSA-N
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| Pharmaceutical Properties |
Molecule Weight
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436.513
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Polar area
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167.93
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Complexity
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31
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xlogp Value
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-2.0188
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Heavy Count
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31
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Rot Bonds
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12
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Hbond acc
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7
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Hbond Donor
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4
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
1F6-Pro- (D)Lys-AF [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) | > 10.00 uM | Positive TNF expression (TNF+++/++) | ||
| Method Description |
IC50 values are the mean and SD of 21 independent experimental titrations, each performed at least in duplicate.
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| In Vitro Model | Renal cell carcinoma | 786-O cells | CVCL_1051 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) | > 10.00 uM | Positive TNF expression (TNF+++/++) | ||
| Method Description |
IC50 values are the mean and SD of 21 independent experimental titrations, each performed at least in duplicate.
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| In Vitro Model | Clear cell renal cell carcinoma | Caki-1 cells | CVCL_0234 | ||
| Experiment 3 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) | > 10.00 uM | Positive TNF expression (TNF+++/++) | ||
| Method Description |
IC50 values are the mean and SD of 21 independent experimental titrations, each performed at least in duplicate.
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| In Vitro Model | Hodgkin lymphoma | L-428 cells | CVCL_1361 | ||
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