Linker Information
General Information of This Linker
| Linker ID |
LIN0IJDBU
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| Linker Name |
LA301-1-1 linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C37H53N11O13S
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| Isosmiles |
O=C(NCC(NC(C(N)=O)CSC(=O)C1CC(=O)NC(=O)C1CCCCCC(NCC(NCC(N[C@H](C(NCC(NCO)=O)=O)CC1=CC=CC=C1)=O)=O)=O)=O)CNC(CN)=O
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| InChI |
InChI=1S/C37H53N11O13S/c38-13-28(52)41-15-30(54)43-18-33(57)47-25(34(39)58)19-62-37(61)23-12-27(51)48-35(59)22(23)9-5-2-6-10-26(50)40-14-29(53)42-17-32(56)46-24(11-21-7-3-1-4-8-21)36(60)44-16-31(55)45-20-49/h1,3-4,7-8,22-25,49H,2,5-6,9-20,38H2,(H2,39,58)(H,40,50)(H,41,52)(H,42,53)(H,43,54)(H,44,60)(H,45,55)(H,46,56)(H,47,57)(H,48,51,59)/t22?,23?,24-,25?/m0/s1
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| InChIKey |
KUHPKHCGFYWACO-YMDASHEASA-N
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| Pharmaceutical Properties |
Molecule Weight
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891.962
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Polar area
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385.38
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Complexity
|
1711.164317
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xlogp Value
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-6.2211
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Heavy Count
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62
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Rot Bonds
|
27
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Hbond acc
|
15
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Hbond Donor
|
12
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Each Antibody-drug Conjugate Related to This Linker