Linker Information
General Information of This Linker
| Linker ID |
LIN0IAETB
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| Linker Name |
Mc-PEG8-Val-Ala-PABC
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C49H82N6O15
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| Isosmiles |
COCCOCCOCCOCCOCCOCCOCCOCCCNCCCCC(NC(=O)CCCCCN1C(=O)C=CC1=O)C(=O)NC(C(=O)NC(C)C(=O)Nc1ccc(CO)cc1)C(C)C
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| InChI |
InChI=1S/C49H82N6O15/c1-38(2)46(49(62)51-39(3)47(60)52-41-15-13-40(37-56)14-16-41)54-48(61)42(53-43(57)12-6-5-9-21-55-44(58)17-18-45(55)59)11-7-8-19-50-20-10-22-64-25-26-66-29-30-68-33-34-70-36-35-69-32-31-67-28-27-65-24-23-63-4/h13-18,38-39,42,46,50,56H,5-12,19-37H2,1-4H3,(H,51,62)(H,52,60)(H,53,57)(H,54,61)
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| InChIKey |
WGNVMMWZDSDFDD-UHFFFAOYSA-N
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| Pharmaceutical Properties |
Molecule Weight
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995.222
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Polar area
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259.88
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Complexity
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70
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xlogp Value
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1.6457
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Heavy Count
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70
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Rot Bonds
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45
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Hbond acc
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16
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Hbond Donor
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6
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
SC16.103-DL5 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) |
0.13 nM
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Positive CD276 expression (CD276 +++/++) | ||
| Method Description |
The anti-tumor activity of these ADCs was tested in cytotoxicity assaysusing the HCC38 cell line. IC50 values were determined by quantitating viable cells using a CellTiter-Glo luminescent assay.
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| In Vitro Model | Breast ductal carcinoma | HCC38 cells | CVCL_1267 | ||
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