Linker Information
General Information of This Linker
| Linker ID |
LIN0HWTMI
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| Linker Name |
NHS-PEG2 linker
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| Linker Type |
Uncleavable linker
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| Antibody-Linker Relation |
Uncleavable
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| Structure |
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| Formula |
C11H18N2O6
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| Isosmiles |
O=C(N1OC(CCOCCOCCN)=O)CCC1=O
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| PubChem CID | ||||||
| InChI |
InChI=1S/C11H18N2O6/c12-4-6-18-8-7-17-5-3-11(16)19-13-9(14)1-2-10(13)15/h1-8,12H2
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| InChIKey |
XFYUIYJXZVROLX-UHFFFAOYSA-N
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| Pharmaceutical Properties |
Molecule Weight
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274.273
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Polar area
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108.16
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Complexity
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292
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xlogp Value
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-1.0244
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Heavy Count
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19
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Rot Bonds
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9
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Hbond acc
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7
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Hbond Donor
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1
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
MORAb-003 ADC10 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | > 500 nM | High FRA expression (FRA +++) | ||
| Method Description |
Use crystal violet analysis to evaluate the in vitro efficacy of the prepared ADCs. Initially screen all MORAb003 ADCs on IGROV1 (FRi (+++)) and SJSA - 1 (FReg (-)) cells.
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| In Vitro Model | Osteosarcoma | SJSA-1 cells | CVCL_1697 | ||