Linker Information
General Information of This Linker
| Linker ID |
LIN0HSKUK
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| Linker Name |
IG-L-25 linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C59H80N14O21
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| Isosmiles |
CN(CC(N(C)CC(N(CC(N(C)CC(N(CC(N(C)CC(N(CC(N(C)CC(N(CC(O)=O)C)=O)=O)C)=O)=O)C)=O)=O)C)=O)=O)C(CN(C)C(CCCOC1=CC(N2C(C=CC2=O)=O)=CC=C1CCC(N[C@@H](CC(N)=O)C(NC3=CC=C(C=C3)COC(O)=O)=O)=O)=O)=O
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| InChI |
InChI=1S/C59H80N14O21/c1-63(45(76)12-11-23-93-42-24-40(73-46(77)21-22-47(73)78)19-15-38(42)16-20-44(75)62-41(25-43(60)74)58(90)61-39-17-13-37(14-18-39)36-94-59(91)92)26-48(79)64(2)27-49(80)65(3)28-50(81)66(4)29-51(82)67(5)30-52(83)68(6)31-53(84)69(7)32-54(85)70(8)33-55(86)71(9)34-56(87)72(10)35-57(88)89/h13-15,17-19,21-22,24,41H,11-12,16,20,23,25-36H2,1-10H3,(H2,60,74)(H,61,90)(H,62,75)(H,88,89)(H,91,92)/t41-/m0/s1
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| InChIKey |
NPPNOJBCNAMDRM-RWYGWLOXSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1321.366
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Polar area
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434.83
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Complexity
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3107.89703
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xlogp Value
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-3.9303
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Heavy Count
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94
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Rot Bonds
|
36
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Hbond acc
|
19
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Hbond Donor
|
5
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Each Antibody-drug Conjugate Related to This Linker