Linker Information
General Information of This Linker
| Linker ID |
LIN0HPLPU
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| Linker Name |
IG-L-37 linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C55H79FN14O20
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| Isosmiles |
C[C@H](NC([C@@H](NC(CCC1=CC=C(N2C(C=CC2=O)=O)C(F)=C1OCCCC(N(C)CC(N(CC(N(C)CC(N(CC(N(C)CC(N(CC(N(C)CC(N(CC(N(C)CC(N(CC(O)=O)C)=O)=O)C)=O)=O)C)=O)=O)C)=O)=O)C)=O)=O)=O)C)=O)C(NCC(O)=O)=O
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| InChI |
InChI=1S/C55H79FN14O20/c1-33(54(88)57-22-50(84)85)59-55(89)34(2)58-37(71)18-16-35-15-17-36(70-39(73)19-20-40(70)74)52(56)53(35)90-21-13-14-38(72)60(3)23-41(75)61(4)24-42(76)62(5)25-43(77)63(6)26-44(78)64(7)27-45(79)65(8)28-46(80)66(9)29-47(81)67(10)30-48(82)68(11)31-49(83)69(12)32-51(86)87/h15,17,19-20,33-34H,13-14,16,18,21-32H2,1-12H3,(H,57,88)(H,58,71)(H,59,89)(H,84,85)(H,86,87)/t33-,34-/m0/s1
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| InChIKey |
FFNARYBUQYOUSG-HEVIKAOCSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1275.313
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Polar area
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411.61
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Complexity
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2834.615641
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xlogp Value
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-5.7745
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Heavy Count
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90
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Rot Bonds
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35
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Hbond acc
|
18
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Hbond Donor
|
5
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Each Antibody-drug Conjugate Related to This Linker