Linker Information
General Information of This Linker
| Linker ID |
LIN0HPGDT
|
|||||
|---|---|---|---|---|---|---|
| Linker Name |
CN119317630A ADC-C14 Linker
|
|||||
| Linker Type |
Cathepsin-cleavable linker
|
|||||
| Antibody-Linker Relation |
Cleavable
|
|||||
| Structure |
|
|||||
| Formula |
C18H27N3O7
|
|||||
| Isosmiles |
CC([C@H](NC(CCCCCN1C(C=CC1=O)=O)=O)C(N[C@@H](CO)C(O)=O)=O)C
|
|||||
| InChI |
InChI=1S/C18H27N3O7/c1-11(2)16(17(26)19-12(10-22)18(27)28)20-13(23)6-4-3-5-9-21-14(24)7-8-15(21)25/h7-8,11-12,16,22H,3-6,9-10H2,1-2H3,(H,19,26)(H,20,23)(H,27,28)/t12-,16-/m0/s1
|
|||||
| InChIKey |
POOVKIXSSJQJDG-LRDDRELGSA-N
|
|||||
| Pharmaceutical Properties |
Molecule Weight
|
397.428
|
Polar area
|
153.11
|
||
|
Complexity
|
591.9495685
|
xlogp Value
|
-0.8257
|
|||
|
Heavy Count
|
28
|
Rot Bonds
|
12
|
|||
|
Hbond acc
|
6
|
Hbond Donor
|
4
|
|||
Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
CN119317630A ADC-C14 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
64 nM
|
|||
| Method Description |
Distribute the cell lines H358 (1E3/well), to 3D-96-well plates (Corning: 4520), with 80 ul/well. Incubate overnight at 37°C and 5% CO2. Detect the cell viability of H358, H441, H1048 and MDA-MB-453 cells using 3D reagent (Promega, G9683).
|
||||
| In Vitro Model | Minimally invasive lung adenocarcinoma | H358 cells | CVCL_1559 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
100 nM
|
|||
| Method Description |
Distribute the cell lines H441 (1E3/well) to 3D-96-well plates (Corning: 4520), with 80 ul/well. Incubate overnight at 37°C and 5% CO2. Detect the cell viability of H358, H441, H1048 and MDA-MB-453 cells using 3D reagent (Promega, G9683).
|
||||
| In Vitro Model | Lung papillary adenocarcinoma | H441 cells | CVCL_1561 | ||
| Experiment 3 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
100 nM
|
|||
| Method Description |
Distribute the cell lines H1048 (1E3/well) to 3D-96-well plates (Corning: 4520), with 80 ul/well. Incubate overnight at 37°C and 5% CO2. Detect the cell viability of H358, H441, H1048 and MDA-MB-453 cells using 3D reagent (Promega, G9683).
|
||||
| In Vitro Model | Lung small cell carcinoma, Small cell lung cancer | H1048 cells | CVCL_1453 | ||