Linker Information
General Information of This Linker
| Linker ID |
LIN0HNWAP
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| Linker Name |
TW202506738A-C-208-LINKER
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C82H136N14O38
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| Isosmiles |
COCCOCCOCCOCCOCCOCCOCCOCCOCC(NCCCC[C@H](NC(CCCNC([C@@H](N1C(C=CC1=O)=O)[C@H](N2C(C=CC2=O)=O)C(NCCCC(N[C@@H](CCCCNC(COCCOCCOCCOCCOCCOCCOCCOCCOC)=O)C(NCC(NCC(NCC(O)=O)=O)=O)=O)=O)=O)=O)=O)C(NCC(NCC(NCC(O)=O)=O)=O)=O)=O
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| InChI |
InChI=1S/C82H136N14O38/c1-117-21-23-119-25-27-121-29-31-123-33-35-125-37-39-127-41-43-129-45-47-131-49-51-133-59-69(103)83-17-5-3-9-61(79(113)91-55-67(101)87-53-65(99)89-57-75(109)110)93-63(97)11-7-19-85-81(115)77(95-71(105)13-14-72(95)106)78(96-73(107)15-16-74(96)108)82(116)86-20-8-12-64(98)94-62(80(114)92-56-68(102)88-54-66(100)90-58-76(111)112)10-4-6-18-84-70(104)60-134-52-50-132-48-46-130-44-42-128-40-38-126-36-34-124-32-30-122-28-26-120-24-22-118-2/h13-16,61-62,77-78H,3-12,17-60H2,1-2H3,(H,83,103)(H,84,104)(H,85,115)(H,86,116)(H,87,101)(H,88,102)(H,89,99)(H,90,100)(H,91,113)(H,92,114)(H,93,97)(H,94,98)(H,109,110)(H,111,112)/t61-,62-,77-,78-/m0/s1
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| InChIKey |
ZRFPFQKWEAYSGB-VSDWSBRVSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1926.05
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Polar area
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664.7
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Complexity
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.
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xlogp Value
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-8.6662
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Heavy Count
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134
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Rot Bonds
|
91
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Hbond acc
|
36
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Hbond Donor
|
14
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Each Antibody-drug Conjugate Related to This Linker