Linker Information
General Information of This Linker
| Linker ID |
LIN0HMEAA
|
|||||
|---|---|---|---|---|---|---|
| Linker Name |
T-2 linker
|
|||||
| Linker Type |
Beta-glucuronide based linker
|
|||||
| Antibody-Linker Relation |
Cleavable
|
|||||
| Structure |
|
|||||
| Formula |
C42H65N5O22S
|
|||||
| Isosmiles |
CN(CCOCCOCCOCCCN1C=C(N=N1)COCCOCCOCCOCCOCCOCCN2C(C=CC2=O)=O)C(C3=CC(OS(O)(=O)=O)=C(O[C@@H]4C(O)[C@@H](O)[C@@H](O)[C@H](O4)CO)C=C3)=O
|
|||||
| InChI |
InChI=1S/C42H65N5O22S/c1-45(41(54)31-3-4-33(34(27-31)69-70(55,56)57)67-42-40(53)39(52)38(51)35(29-48)68-42)8-11-59-14-17-61-16-13-58-10-2-7-46-28-32(43-44-46)30-66-26-25-65-24-23-64-22-21-63-20-19-62-18-15-60-12-9-47-36(49)5-6-37(47)50/h3-6,27-28,35,38-40,42,48,51-53H,2,7-26,29-30H2,1H3,(H,55,56,57)/t35-,38+,39+,40?,42+/m1/s1
|
|||||
| InChIKey |
CVYYKZFVWXRSFR-FBMHUHODSA-N
|
|||||
| Pharmaceutical Properties |
Molecule Weight
|
1024.062
|
Polar area
|
334.45
|
||
|
Complexity
|
1865.922057
|
xlogp Value
|
-2.6249
|
|||
|
Heavy Count
|
70
|
Rot Bonds
|
39
|
|||
|
Hbond acc
|
24
|
Hbond Donor
|
5
|
|||
Each Antibody-drug Conjugate Related to This Linker