Linker Information
General Information of This Linker
| Linker ID |
LIN0HKUTH
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| Linker Name |
AU2023279443A1, Example A21, Linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C53H84N12O23P2
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| Isosmiles |
CC(C)[C@H](NC([C@@H](NC([C@H](CCCCN(C)C)NC(CCOCCOCCOP(OCCNC([C@@H](N1C(C=CC1=O)=O)CNC(CCP(O)(O)=O)=O)=O)(O)=O)=O)=O)CC(N[C@H]2CCOC2=O)=O)=O)C(N[C@H](C(NC3=CC=C(CO)C=C3)=O)CCCNC(N)=O)=O
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| InChI |
InChI=1S/C53H84N12O23P2/c1-33(2)46(51(76)61-37(9-7-19-56-53(54)78)47(72)58-35-12-10-34(32-66)11-13-35)63-49(74)39(30-43(69)60-38-16-23-86-52(38)77)62-48(73)36(8-5-6-21-64(3)4)59-42(68)17-22-84-25-26-85-27-28-88-90(82,83)87-24-20-55-50(75)40(65-44(70)14-15-45(65)71)31-57-41(67)18-29-89(79,80)81/h10-15,33,36-40,46,66H,5-9,16-32H2,1-4H3,(H,55,75)(H,57,67)(H,58,72)(H,59,68)(H,60,69)(H,61,76)(H,62,73)(H,63,74)(H,82,83)(H3,54,56,78)(H2,79,80,81)/t36-,37-,38-,39-,40-,46-/m0/s1
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| InChIKey |
XAFMIHZAYLOMFG-ZVNYPHDXSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1319.264
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Polar area
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506.82
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Complexity
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2602.992572
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xlogp Value
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-3.6345
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Heavy Count
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90
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Rot Bonds
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44
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Hbond acc
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21
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Hbond Donor
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14
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
AU2023279443A1 Example A21 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Cell growth inhibition rate (%) | > 14% | Positive HER2 expression (HER2+++/++) | ||
| Method Description |
Cell growth inhibition test was carried out on HER2-positive human gastric cancer cell line (NCI-N87), the cells were treated with a test compound or an anti-HER2 antibody (trastuzumab) at a concentration of 100 ng/mL. The cells were cultured for 6 days, then CellTiter-Glo was added and the luminescence amount was measured.
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| In Vitro Model | Gastric tubular adenocarcinoma | NCI-N87 cells | CVCL_1603 | ||