Linker Information
General Information of This Linker
| Linker ID |
LIN0HFQBD
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| Linker Name |
Aminobenzazepine-linker Formula II-17
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| Linker Type |
Unclear
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C60H106F4O29
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| Isosmiles |
FC1=C(OC(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(O)=O)=O)C(F)=C(F)C=C1F
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| InChI |
InChI=1S/C60H106F4O29/c61-54-53-55(62)59(64)60(58(54)63)93-57(67)2-4-69-6-8-71-10-12-73-14-16-75-18-20-77-22-24-79-26-28-81-30-32-83-34-36-85-38-40-87-42-44-89-46-48-91-50-52-92-51-49-90-47-45-88-43-41-86-39-37-84-35-33-82-31-29-80-27-25-78-23-21-76-19-17-74-15-13-72-11-9-70-7-5-68-3-1-56(65)66/h53H,1-52H2,(H,65,66)
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| InChIKey |
CRNLDWZERHFPIV-UHFFFAOYSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1367.471
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Polar area
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294.35
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Complexity
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1614.550279
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xlogp Value
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2.4282
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Heavy Count
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93
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Rot Bonds
|
79
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Hbond acc
|
28
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Hbond Donor
|
1
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
AU2020291014A1 IC-11 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) | > 1000 nM | |||
| Method Description |
Mycloid TNFa Secretion
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| In Vitro Model | Mycloid | Mycloid cells | Homo sapiens | ||
AU2020291014A1 IC-12 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) | > 1000 nM | |||
| Method Description |
Mycloid TNFa Secretion
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| In Vitro Model | Mycloid | Mycloid cells | Homo sapiens | ||
AU2020291014A1 IC-13 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) | > 1000 nM | |||
| Method Description |
Mycloid TNFa Secretion
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| In Vitro Model | Mycloid | Mycloid cells | Homo sapiens | ||
AU2020291014A1 IC-14 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) | > 1000 nM | |||
| Method Description |
Mycloid TNFa Secretion
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| In Vitro Model | Mycloid | Mycloid cells | Homo sapiens | ||