Linker Information

General Information of This Linker
Linker ID
LIN0HCXGU
Linker Name
Photocaged C4AP
Linker Type
Thiol-sensitive linker
Antibody-Linker Relation
Cleavable
Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
Trastuzumab-PC4AP-DOX [Investigative]
 ADC Info 
Revealed Based on the Cell Line Data
Click To Hide/Show 2 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal Inhibitory Concentration (IC50)
203 nM
Positive HER2 expression (HER2 +++/++)
Method Description
SK-BR-3 cells were incubated with 500 nM of trastuzumab and 39 respectively for 30 min at rt, followed by incubation After washing 3 times with PBS, cells were stained with DAPI (300 uL, 10 ug/mL) at rt for 7 min.
In Vitro Model Breast adenocarcinoma SK-BR-3 cells CVCL_0033
Experiment 2 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal Inhibitory Concentration (IC50) > 1000 nM Negative HER2 expression (HER2 -)
Method Description
MCF7 cells were incubated with 500 nM of trastuzumab and 39 respectively for 30 min at rt, followed by incubation After washing 3 times with PBS, cells were stained with DAPI (300 uL, 10 ug/mL) at rt for 7 min.
In Vitro Model Invasive breast carcinoma MCF-7 cells CVCL_0031
References
Ref 1 A light-responsive, self-immolative linker for controlled drug delivery via peptide- and protein-drug conjugates. Chem Sci. 2019 Aug 19;10(39):8973-8980. doi: 10.1039/c9sc03016f. eCollection 2019 Oct 21.

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