Linker Information
General Information of This Linker
| Linker ID |
LIN0HBKLO
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| Linker Name |
COT-EDA- (GLC)PAB linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Formula |
C27H37N3O11
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| Isosmiles |
OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](OC2=CC=C(C=C2C(NCCNC(COC3CCCCCC#C3)=O)=O)COC(N)=O)O1
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| InChI |
InChI=1S/C27H37N3O11/c28-27(37)39-14-16-8-9-19(40-26-24(35)23(34)22(33)20(13-31)41-26)18(12-16)25(36)30-11-10-29-21(32)15-38-17-6-4-2-1-3-5-7-17/h8-9,12,17,20,22-24,26,31,33-35H,1-4,6,10-11,13-15H2,(H2,28,37)(H,29,32)(H,30,36)/t17?,20-,22-,23+,24-,26-/m1/s1
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| InChIKey |
XKPGAKHLWIDPOP-QTLUJHNVSA-N
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| Pharmaceutical Properties |
Molecule Weight
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579.603
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Polar area
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219.13
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Complexity
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1055.244629
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xlogp Value
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-1.3407
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Heavy Count
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41
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Rot Bonds
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12
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Hbond acc
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11
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Hbond Donor
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7
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
TRSQ-ZP3A- LP26-Ve [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
0.087 nM
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Positive HER2 expression (HER2+++/++) | ||
| Method Description |
The anti-proliferation test was carried out with SK-BR-3 human breast cancer cell line. Cells were grown in McCoy's 5a medium supplemented with 36% FBS,penicillin/streptomycin and L-glutamine.
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| In Vitro Model | Breast adenocarcinoma | SK-BR-3 cells | CVCL_0033 | ||
CTRL-ZP3A- LP26-Ve [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
3.282 nM
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Positive HER2 expression (HER2+++/++) | ||
| Method Description |
The anti-proliferation test was carried out with SK-BR-3 human breast cancer cell line. Cells were grown in McCoy's 5a medium supplemented with 37% FBS,penicillin/streptomycin and L-glutamine.
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| In Vitro Model | Breast adenocarcinoma | SK-BR-3 cells | CVCL_0033 | ||