Linker Information
General Information of This Linker
| Linker ID |
LIN0HBIXZ
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| Linker Name |
Anti-Her2-AL1- LP35 LINKER linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C74H116N16O26
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| Isosmiles |
NCCOCCOCCOCCN(N=N1)C2=C1C(OCC(NCCOCCOCCOCCN(CC(NCCOCCOCCC(NCC(NCC(N[C@@H](CC3=CC=CC=C3)C(NCC(O)=O)=O)=O)=O)=O)=O)CC(NCCOCCOCCC(NCC(NCC(N[C@@H](CC4=CC=CC=C4)C(NCC(O)=O)=O)=O)=O)=O)=O)=O)CCCCC2
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| InChI |
InChI=1S/C74H116N16O26/c75-18-26-108-34-40-114-43-39-113-31-23-90-59-14-8-3-9-15-60(72(59)87-88-90)116-54-69(99)78-21-29-111-37-41-115-42-38-112-30-22-89(52-67(97)76-19-27-109-35-32-106-24-16-61(91)79-46-63(93)81-48-65(95)85-57(73(104)83-50-70(100)101)44-55-10-4-1-5-11-55)53-68(98)77-20-28-110-36-33-107-25-17-62(92)80-47-64(94)82-49-66(96)86-58(74(105)84-51-71(102)103)45-56-12-6-2-7-13-56/h1-2,4-7,10-13,57-58,60H,3,8-9,14-54,75H2,(H,76,97)(H,77,98)(H,78,99)(H,79,91)(H,80,92)(H,81,93)(H,82,94)(H,83,104)(H,84,105)(H,85,95)(H,86,96)(H,100,101)(H,102,103)/t57-,58-,60?/m0/s1
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| InChIKey |
GYWZMPMQZXSDBJ-DFHSDXQRSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1645.828
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Polar area
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556.2
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Complexity
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3064.710949
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xlogp Value
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-5.6708
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Heavy Count
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116
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Rot Bonds
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68
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Hbond acc
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29
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Hbond Donor
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14
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Each Antibody-drug Conjugate Related to This Linker