Linker Information

General Information of This Linker
Linker ID
LIN0GRWTB
Linker Name
Mal-PEG4-Ala
Linker Type
Thiol-sensitive linker
Antibody-Linker Relation
Cleavable
Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
cot-APTEDB-SN38 [Investigative]
 ADC Info 
Discovered Using Cell Line-derived Xenograft Model
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Tumor Growth Inhibition value (TGI) ≈ 22.20% (Day 8) Positive EDB expression (EDB +++/++)
Method Description
BALB/c nude mice bearing U87MG tumors (450 mm3) were injected intravenously via the tail vein with Abcot (10 mg/kg) or cot-APTEDB-SN38 (equivalent to 2 mg SN38/kg).
In Vivo Model U87MG CDX model
In Vitro Model Glioblastoma U-87MG cells CVCL_0022
References
Ref 1 Antibody-Assisted Delivery of a Peptide-Drug Conjugate for Targeted Cancer Therapy. Mol Pharm. 2019 Jan 7;16(1):165-172. doi: 10.1021/acs.molpharmaceut.8b00924. Epub 2018 Dec 17.

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