Linker Information
General Information of This Linker
| Linker ID |
LIN0GKUTR
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| Linker Name |
(Linker-02)MC-PEG-VA-PAB
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C41H65N5O15
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| Isosmiles |
CC([C@@H](NC(CCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCN1C(C=CC1=O)=O)=O)=O)C(N[C@@H](C)C(NC2=CC=C(C=C2)CO)=O)=O)C
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| InChI |
InChI=1S/C41H65N5O15/c1-31(2)39(41(53)43-32(3)40(52)44-34-6-4-33(30-47)5-7-34)45-36(49)11-14-54-16-18-56-20-22-58-24-26-60-28-29-61-27-25-59-23-21-57-19-17-55-15-12-42-35(48)10-13-46-37(50)8-9-38(46)51/h4-9,31-32,39,47H,10-30H2,1-3H3,(H,42,48)(H,43,53)(H,44,52)(H,45,49)/t32-,39+/m0/s1
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| InChIKey |
YJYDWLGCCNOUSJ-NXVGIJDASA-N
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| Pharmaceutical Properties |
Molecule Weight
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867.991
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Polar area
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247.85
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Complexity
|
1373.587817
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xlogp Value
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-0.2829
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Heavy Count
|
61
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Rot Bonds
|
37
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Hbond acc
|
15
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Hbond Donor
|
5
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
wO2024169913A1 ADC01-08-8 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
0.0089 nM
|
High HER2 expression (HER2+++) | ||
| Method Description |
Cytotoxicity of ADC to SK-BR-3 cells
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| In Vitro Model | Breast adenocarcinoma | SK-BR-3 cells | CVCL_0033 | ||
wO2024169913A1 ADC04-08-8 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
0.118 nM
|
High DLL3 expression (DLL3+++) | ||
| Method Description |
Cytotoxicity of ADC to NCI-H82 cells
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| In Vitro Model | Lung small cell carcinoma | NCI-H82 cells | CVCL_1591 | ||