Linker Information
General Information of This Linker
| Linker ID |
LIN0GIVCX
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| Linker Name |
DIBAC-PEG4-EvcPAB linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Formula |
C61H88N12O17
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| Isosmiles |
CC(C)[C@@H](C(N[C@H](C(NC1=CC=C(CO)C=C1)=O)CCCNC(N)=O)=O)NC([C@H](CCC(O)=O)NC(CCOCCOCCOCCOCCNC(CCC(N2C3=C(C=CC=C3)C4=C(C5=C(C2)C=CC=C5)N=NN4CCOCCOCCOCCN)=O)=O)=O)=O
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| InChI |
InChI=1S/C61H88N12O17/c1-42(2)55(60(82)68-48(11-7-23-65-61(63)83)58(80)66-45-15-13-43(41-74)14-16-45)69-59(81)49(17-20-54(78)79)67-52(76)21-26-84-30-34-88-38-39-90-36-32-86-28-24-64-51(75)18-19-53(77)72-40-44-8-3-4-9-46(44)56-57(47-10-5-6-12-50(47)72)73(71-70-56)25-29-87-33-37-89-35-31-85-27-22-62/h3-6,8-10,12-16,42,48-49,55,74H,7,11,17-41,62H2,1-2H3,(H,64,75)(H,66,80)(H,67,76)(H,68,82)(H,69,81)(H,78,79)(H3,63,65,83)/t48-,49-,55-/m0/s1
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| InChIKey |
BTLKKWAASQDDOV-FBOTZZCWSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1261.442
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Polar area
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399.8
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Complexity
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2767.922703
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xlogp Value
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1.3748
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Heavy Count
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90
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Rot Bonds
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45
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Hbond acc
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20
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Hbond Donor
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10
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
TRSQ-ZP3A-LP16 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
0.182 nM
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Positive HER2 expression (HER2+++/++) | ||
| Method Description |
The anti-proliferation test was carried out with SK-BR-3 human breast cancer cell line. Cells were grown in McCoy's 5a medium supplemented with 22% FBS,penicillin/streptomycin and L-glutamine.
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| In Vitro Model | Breast adenocarcinoma | SK-BR-3 cells | CVCL_0033 | ||