Linker Information
General Information of This Linker
| Linker ID |
LIN0GFUSD
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| Linker Name |
EP4487874A1-17linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C62H104N11O32P3
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| Isosmiles |
CC([C@H](NC([C@@H](NCCCOCCOCCOCCOCCNC([C@@H](N1C(C=CC1=O)=O)CNC(CCOCCOCCOCCOCCOCCC(NCCCC(O)(P(O)(O)=O)P(O)(O)=O)=O)=O)=O)CC(N[C@@H](CCO2)C2=O)=O)=O)C(N[C@@H](CCCNC(N)=O)C(NC3=CC=C(C=C3)COP(O)(O)=O)=O)=O)C
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| InChI |
InChI=1S/C62H104N11O32P3/c1-43(2)55(59(82)71-46(6-3-17-67-61(63)84)56(79)69-45-9-7-44(8-10-45)42-105-108(92,93)94)72-57(80)48(40-52(76)70-47-13-24-104-60(47)83)64-19-5-21-95-26-30-99-34-37-102-33-29-98-25-20-66-58(81)49(73-53(77)11-12-54(73)78)41-68-51(75)15-23-97-28-32-101-36-39-103-38-35-100-31-27-96-22-14-50(74)65-18-4-16-62(85,106(86,87)88)107(89,90)91/h7-12,43,46-49,55,64,85H,3-6,13-42H2,1-2H3,(H,65,74)(H,66,81)(H,68,75)(H,69,79)(H,70,76)(H,71,82)(H,72,80)(H3,63,67,84)(H2,86,87,88)(H2,89,90,91)(H2,92,93,94)/t46-,47-,48-,49-,55-/m0/s1
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| InChIKey |
HABDGFUEXUOJRX-VWHVSXIKSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1608.481
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Polar area
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619.65
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Complexity
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2964.422493
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xlogp Value
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-4.1679
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Heavy Count
|
108
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Rot Bonds
|
62
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Hbond acc
|
27
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Hbond Donor
|
17
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Each Antibody-drug Conjugate Related to This Linker