Linker Information
General Information of This Linker
| Linker ID |
LIN0GFTPO
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| Linker Name |
KGDEVD linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C45H63N9O17
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| Isosmiles |
CC([C@H](NC([C@H](CCC(O)=O)NC([C@@H](NC(CNC([C@@H](NC(C)=O)CCCCNC(CCCCCN1C(C=CC1=O)=O)=O)=O)=O)CC(O)=O)=O)=O)C(N[C@@H](CC(O)=O)C(NC2=CC=C(CO)C=C2)=O)=O)C
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| InChI |
InChI=1S/C45H63N9O17/c1-25(2)40(45(71)52-32(22-39(65)66)43(69)49-28-13-11-27(24-55)12-14-28)53-42(68)30(15-18-37(61)62)51-44(70)31(21-38(63)64)50-34(58)23-47-41(67)29(48-26(3)56)9-6-7-19-46-33(57)10-5-4-8-20-54-35(59)16-17-36(54)60/h11-14,16-17,25,29-32,40,55H,4-10,15,18-24H2,1-3H3,(H,46,57)(H,47,67)(H,48,56)(H,49,69)(H,50,58)(H,51,70)(H,52,71)(H,53,68)(H,61,62)(H,63,64)(H,65,66)/t29-,30-,31-,32-,40-/m0/s1
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| InChIKey |
ULLTYZUMRVQCIP-XWQNLVOPSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1002.045
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Polar area
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402.31
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Complexity
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2037.611965
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xlogp Value
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-2.0804
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Heavy Count
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71
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Rot Bonds
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33
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Hbond acc
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14
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Hbond Donor
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12
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
uS20240091372A1 3H9-KGDEVD-MMAE [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
39.32 Nm
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| Method Description |
A cell line expressing doppel, HCT116, was selected and cultured with increasing concentrations of ADC. After 72 hours, viability of each culture was assessed. ICso values were calculated by logistic non-linear regression and reported as nM.
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| In Vitro Model | Colon carcinoma | HCT116 cells | CVCL_0291 | ||