Linker Information
General Information of This Linker
| Linker ID |
LIN0GFJRP
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| Linker Name |
Linker of ADC2-33
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C40H54N8O18
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| Isosmiles |
O=C(NCC(NCC(N[C@H](C(NCC(O)=O)=O)CC1=CC=CC=C1)=O)=O)[C@H](CCC(NC(O2)[C@H](O)[C@H](O)C2C(NC(O3)[C@H](O)[C@H](O)[C@H]3CO)=O)=O)NC(CCCCCN4C(C=CC4=O)=O)=O
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| InChI |
InChI=1S/C40H54N8O18/c49-19-23-31(58)33(60)40(65-23)47-38(64)35-32(59)34(61)39(66-35)46-25(51)11-10-21(44-24(50)9-5-2-6-14-48-28(54)12-13-29(48)55)36(62)42-16-26(52)41-17-27(53)45-22(37(63)43-18-30(56)57)15-20-7-3-1-4-8-20/h1,3-4,7-8,12-13,21-23,31-35,39-40,49,58-61H,2,5-6,9-11,14-19H2,(H,41,52)(H,42,62)(H,43,63)(H,44,50)(H,45,53)(H,46,51)(H,47,64)(H,56,57)/t21-,22-,23+,31+,32-,33+,34+,35?,39?,40?/m0/s1
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| InChIKey |
CQZXNOVKPIEHKW-NHTSGHDPSA-N
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| Pharmaceutical Properties |
Molecule Weight
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934.91
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Polar area
|
397.99
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Complexity
|
1867.062753
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xlogp Value
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-6.9844
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Heavy Count
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66
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Rot Bonds
|
25
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Hbond acc
|
17
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Hbond Donor
|
13
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Each Antibody-drug Conjugate Related to This Linker