Linker Information
General Information of This Linker
| Linker ID |
LIN0GDIPX
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| Linker Name |
DIBAC-PEG4-GGG linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Formula |
C38H51N7O10
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| Isosmiles |
NCCNC(CNC(CNC(CNC(CCOCCOCCOCCOCCNC(CCC(N(C(C=CC=C1)=C1C#C2)CC3=C2C=CC=C3)=O)=O)=O)=O)=O)=O
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| InChI |
InChI=1S/C38H51N7O10/c39-14-15-40-35(48)25-43-37(50)27-44-36(49)26-42-34(47)13-17-52-19-21-54-23-24-55-22-20-53-18-16-41-33(46)11-12-38(51)45-28-31-7-2-1-5-29(31)9-10-30-6-3-4-8-32(30)45/h1-8H,11-28,39H2,(H,40,48)(H,41,46)(H,42,47)(H,43,50)(H,44,49)
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| InChIKey |
QTDHCRVFINVFSQ-UHFFFAOYSA-N
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| Pharmaceutical Properties |
Molecule Weight
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765.865
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Polar area
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228.75
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Complexity
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1562.127631
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xlogp Value
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-1.2906
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Heavy Count
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55
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Rot Bonds
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26
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Hbond acc
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11
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Hbond Donor
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6
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
TRSQ-ZP3A-LP18 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
0.118 nM
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Positive HER2 expression (HER2+++/++) | ||
| Method Description |
The anti-proliferation test was carried out with SK-BR-3 human breast cancer cell line. Cells were grown in McCoy's 5a medium supplemented with 23% FBS,penicillin/streptomycin and L-glutamine.
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| In Vitro Model | Breast adenocarcinoma | SK-BR-3 cells | CVCL_0033 | ||