Linker Information
General Information of This Linker
| Linker ID |
LIN0GAPRB
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| Linker Name |
WO2024140449A1+ADC7+Linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C21H39BrN4O9
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| Isosmiles |
O=C(NCC(N[C@@H](CCCCN)C(O)=O)=O)CCOCCOCCOCCOCCNC(CBr)=O
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| InChI |
InChI=1S/C21H39BrN4O9/c22-15-19(28)24-6-8-33-10-12-35-14-13-34-11-9-32-7-4-18(27)25-16-20(29)26-17(21(30)31)3-1-2-5-23/h17H,1-16,23H2,(H,24,28)(H,25,27)(H,26,29)(H,30,31)/t17-/m0/s1
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| InChIKey |
VHHLFZTXNDCCSQ-KRWDZBQOSA-N
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| Pharmaceutical Properties |
Molecule Weight
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571.466
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Polar area
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187.54
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Complexity
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548.385619
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xlogp Value
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-1.2314
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Heavy Count
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35
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Rot Bonds
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24
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Hbond acc
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9
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Hbond Donor
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5
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
wO2024140449A1 ADC8 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
50-500 nM
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| Method Description |
A Cell line test on OE-33
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| In Vitro Model | Barrett adenocarcinoma, Adenocarcinoma of the esophagus | OE-33 cells | CVCL_0471 | ||
wO2024140449A1 ADC7 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | > 250 nM | |||
| Method Description |
A Cell line test on OE-33
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| In Vitro Model | Barrett adenocarcinoma, Adenocarcinoma of the esophagus | OE-33 cells | CVCL_0471 | ||