Linker Information
General Information of This Linker
| Linker ID |
LIN0GAPLW
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| Linker Name |
ADC 3-5 linker
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| Antibody-Linker Relation |
Cleavable
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
ADC3-5 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Maximum inhibition efficiency (MIE) |
62.80%
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Positive HER2 expression (HER2 +++/++) | ||
| Method Description |
Seeding cells (HCC1569) into 96-well plate, at 2E3 cell per well (80 uL/well). Overnight incubation.
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| In Vitro Model | Breast ductal carcinoma | HCC1569 cells | CVCL_1255 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
4.36 nM
|
Positive HER2 expression (HER2 +++/++) | ||
| Method Description |
Seeding cells (HCC1569) into 96-well plate, at 2E3 cell per well (80 uL/well). Overnight incubation.
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| In Vitro Model | Breast ductal carcinoma | HCC1569 cells | CVCL_1255 | ||
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