Linker Information
General Information of This Linker
| Linker ID |
LIN0FZBMN
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| Linker Name |
COT-GGGG linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Formula |
C18H27N5O6
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| Isosmiles |
O=C(NCC(NCC(NCC(NCC(N)=O)=O)=O)=O)COC1C#CCCCCC1
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| InChI |
InChI=1S/C18H27N5O6/c19-14(24)8-20-15(25)9-21-16(26)10-22-17(27)11-23-18(28)12-29-13-6-4-2-1-3-5-7-13/h13H,1-4,6,8-12H2,(H2,19,24)(H,20,25)(H,21,26)(H,22,27)(H,23,28)
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| InChIKey |
IMAWKTVBBRNSPF-UHFFFAOYSA-N
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| Pharmaceutical Properties |
Molecule Weight
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409.443
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Polar area
|
168.72
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Complexity
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630.6847991
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xlogp Value
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-2.7108
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Heavy Count
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29
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Rot Bonds
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11
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Hbond acc
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6
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Hbond Donor
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5
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
TRSQ-ZP3A- LP19-Ve [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
0.029 nM
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Positive HER2 expression (HER2+++/++) | ||
| Method Description |
The anti-proliferation test was carried out with SK-BR-3 human breast cancer cell line. Cells were grown in McCoy's 5a medium supplemented with 40% FBS,penicillin/streptomycin and L-glutamine.
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| In Vitro Model | Breast adenocarcinoma | SK-BR-3 cells | CVCL_0033 | ||
TRSQ-ZP3A- LP23-Vb [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
0.063 nM
|
Positive HER2 expression (HER2+++/++) | ||
| Method Description |
The anti-proliferation test was carried out with SK-BR-3 human breast cancer cell line. Cells were grown in McCoy's 5a medium supplemented with 45% FBS,penicillin/streptomycin and L-glutamine.
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| In Vitro Model | Breast adenocarcinoma | SK-BR-3 cells | CVCL_0033 | ||