Linker Information
General Information of This Linker
| Linker ID |
LIN0FYFHS
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| Linker Name |
Mal-Exo-EVC
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C35H50N8O11
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| Isosmiles |
CC(C)[C@H](NC([C@@H](NC(C)=O)CCC(O)=O)=O)C(N[C@H](C(NC1=CC=C(C(O)C(NCCCCCN2C(C=CC2=O)=O)=O)C=C1)=O)CCCNC(N)=O)=O
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| InChI |
InChI=1S/C35H50N8O11/c1-20(2)29(42-32(51)25(39-21(3)44)13-16-28(47)48)33(52)41-24(8-7-18-38-35(36)54)31(50)40-23-11-9-22(10-12-23)30(49)34(53)37-17-5-4-6-19-43-26(45)14-15-27(43)46/h9-12,14-15,20,24-25,29-30,49H,4-8,13,16-19H2,1-3H3,(H,37,53)(H,39,44)(H,40,50)(H,41,52)(H,42,51)(H,47,48)(H3,36,38,54)/t24-,25-,29-,30?/m0/s1
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| InChIKey |
NDGUSJKCIQQSDS-VYKFGDEHSA-N
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| Pharmaceutical Properties |
Molecule Weight
|
758.83
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Polar area
|
295.53
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Complexity
|
1476.949476
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xlogp Value
|
-0.6864
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Heavy Count
|
54
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Rot Bonds
|
23
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Hbond acc
|
10
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Hbond Donor
|
9
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Each Antibody-drug Conjugate Related to This Linker