Linker Information
General Information of This Linker
| Linker ID |
LIN0FUEPN
|
|||||
|---|---|---|---|---|---|---|
| Linker Name |
Anti-Her2-AL1- LP28 linker
|
|||||
| Linker Type |
Cathepsin-cleavable linker
|
|||||
| Antibody-Linker Relation |
Cleavable
|
|||||
| Structure |
|
|||||
| Formula |
C99H159N23O38
|
|||||
| Isosmiles |
NCCOCCOCCOCCN1N=NC2=C1CCCCC(OCC(NCCOCCOCCOCCN(CC(NCCOCCOCCC(N[C@@H](C(N[C@@H](C(C)C)C(N[C@H](C(NC3=CC=C(COC(NCC(O)=O)=O)C=C3)=O)CCCNC(N)=O)=O)=O)CCC(O)=O)=O)=O)CC(NCCOCCOCCC(N[C@@H](C(N[C@@H](C(C)C)C(N[C@H](C(NC4=CC=C(COC(NCC(NCOCC(O)=O)=O)=O)C=C4)=O)CCCNC(N)=O)=O)=O)CCC(O)=O)=O)=O)=O)C2
|
|||||
| InChI |
InChI=1S/C99H159N23O38/c1-65(2)88(94(141)115-72(10-7-28-106-96(101)143)90(137)111-69-17-13-67(14-18-69)60-159-98(145)108-56-80(125)110-64-157-63-87(135)136)117-92(139)74(21-23-84(129)130)113-78(123)25-35-147-43-46-150-38-30-103-81(126)58-121(33-41-153-49-53-156-52-48-152-40-32-105-83(128)62-158-71-9-5-6-12-77-76(55-71)119-120-122(77)34-42-154-50-54-155-51-45-149-37-27-100)59-82(127)104-31-39-151-47-44-148-36-26-79(124)114-75(22-24-85(131)132)93(140)118-89(66(3)4)95(142)116-73(11-8-29-107-97(102)144)91(138)112-70-19-15-68(16-20-70)61-160-99(146)109-57-86(133)134/h13-20,65-66,71-75,88-89H,5-12,21-64,100H2,1-4H3,(H,103,126)(H,104,127)(H,105,128)(H,108,145)(H,109,146)(H,110,125)(H,111,137)(H,112,138)(H,113,123)(H,114,124)(H,115,141)(H,116,142)(H,117,139)(H,118,140)(H,129,130)(H,131,132)(H,133,134)(H,135,136)(H3,101,106,143)(H3,102,107,144)/t71?,72-,73-,74+,75+,88-,89-/m0/s1
|
|||||
| InChIKey |
DLQZZGBFKXYZST-LGPDNCOHSA-N
|
|||||
| Pharmaceutical Properties |
Molecule Weight
|
2279.484
|
Polar area
|
856.03
|
||
|
Complexity
|
.
|
xlogp Value
|
-4.6756
|
|||
|
Heavy Count
|
160
|
Rot Bonds
|
90
|
|||
|
Hbond acc
|
39
|
Hbond Donor
|
23
|
|||
Each Antibody-drug Conjugate Related to This Linker
