Linker Information
General Information of This Linker
| Linker ID |
LIN0FTDIZ
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| Linker Name |
Linker of ADC2-30
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C37H50N8O14
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| Isosmiles |
O=C(NCC(NCC(N[C@H](C(NCC(O)=O)=O)CC1=CC=CC=C1)=O)=O)[C@@H](NC(CCCCCN2C(C=CC2=O)=O)=O)CCC(NC[C@@H](O3)[C@@H](O)[C@@H](O)[C@@H]3CC(N)=O)=O
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| InChI |
InChI=1S/C37H50N8O14/c38-26(46)16-24-34(55)35(56)25(59-24)17-39-27(47)11-10-22(43-28(48)9-5-2-6-14-45-31(51)12-13-32(45)52)36(57)41-18-29(49)40-19-30(50)44-23(37(58)42-20-33(53)54)15-21-7-3-1-4-8-21/h1,3-4,7-8,12-13,22-25,34-35,55-56H,2,5-6,9-11,14-20H2,(H2,38,46)(H,39,47)(H,40,49)(H,41,57)(H,42,58)(H,43,48)(H,44,50)(H,53,54)/t22-,23-,24-,25+,34-,35+/m0/s1
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| InChIKey |
ZJJITHTVROZMEU-ZUJRIHCJSA-N
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| Pharmaceutical Properties |
Molecule Weight
|
830.849
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Polar area
|
342.06
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Complexity
|
1646.627513
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xlogp Value
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-4.6217
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Heavy Count
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59
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Rot Bonds
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25
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Hbond acc
|
13
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Hbond Donor
|
10
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Each Antibody-drug Conjugate Related to This Linker