Linker Information
General Information of This Linker
| Linker ID |
LIN0FTACX
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| Linker Name |
MA-VAG-P12
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C88H155N7O39
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| Isosmiles |
O=C(CCNC(OCC(COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC)(COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC)NC(CCCC(CNC(C(NC(C(NC(C1CCC(CN2C(C=CC2=O)=O)CC1)=O)C(C)C)=O)C)=O)=O)=O)=O)ON3C(CCC3=O)=O
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| InChI |
InChI=1S/C88H155N7O39/c1-72(2)83(92-85(104)75-11-9-74(10-12-75)68-94-78(98)13-14-79(94)99)86(105)91-73(3)84(103)90-67-76(96)7-6-8-77(97)93-88(71-133-87(106)89-18-17-82(102)134-95-80(100)15-16-81(95)101,69-131-65-63-129-61-59-127-57-55-125-53-51-123-49-47-121-45-43-119-41-39-117-37-35-115-33-31-113-29-27-111-25-23-109-21-19-107-4)70-132-66-64-130-62-60-128-58-56-126-54-52-124-50-48-122-46-44-120-42-40-118-38-36-116-34-32-114-30-28-112-26-24-110-22-20-108-5/h13-14,72-75,83H,6-12,15-71H2,1-5H3,(H,89,106)(H,90,103)(H,91,105)(H,92,104)(H,93,97)
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| InChIKey |
HRIZHZMSEYAHJB-UHFFFAOYSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1935.218
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Polar area
|
512.84
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Complexity
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.
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xlogp Value
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-0.5114
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Heavy Count
|
134
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Rot Bonds
|
97
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Hbond acc
|
39
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Hbond Donor
|
5
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Each Antibody-drug Conjugate Related to This Linker