Linker Information
General Information of This Linker
| Linker ID |
LIN0FQJWR
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| Linker Name |
CN110997010A ADC-1 linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C55H76N10O19S2
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| Isosmiles |
CC(C)[C@H](NC(CCCCCN1C(C=CC1=O)=O)=O)C(N[C@H](C(NC2=CC=C(COC(NC(CSC(CC3=O)C(N3CCCCCC(O)=O)=O)C(NC(C(O)=O)CSC(C4=O)CC(N4CCCCCC(O)=O)=O)=O)=O)C=C2)=O)CCCNC(N)=O)=O
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| InChI |
InChI=1S/C55H76N10O19S2/c1-32(2)47(62-40(66)14-6-3-9-24-63-41(67)21-22-42(63)68)50(77)59-35(13-12-23-57-54(56)82)48(75)58-34-19-17-33(18-20-34)29-84-55(83)61-36(30-85-38-27-43(69)64(51(38)78)25-10-4-7-15-45(71)72)49(76)60-37(53(80)81)31-86-39-28-44(70)65(52(39)79)26-11-5-8-16-46(73)74/h17-22,32,35-39,47H,3-16,23-31H2,1-2H3,(H,58,75)(H,59,77)(H,60,76)(H,61,83)(H,62,66)(H,71,72)(H,73,74)(H,80,81)(H3,56,57,82)/t35-,36?,37?,38?,39?,47-/m0/s1
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| InChIKey |
ZDTWFALUAYRODC-ZZWAWIPZSA-N
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| Pharmaceutical Properties |
Molecule Weight
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1245.398
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Polar area
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433.89
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Complexity
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2557.373369
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xlogp Value
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1.3602
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Heavy Count
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86
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Rot Bonds
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40
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Hbond acc
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18
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Hbond Donor
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10
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Each Antibody-drug Conjugate Related to This Linker